PierianDx enables clinical labs to launch or accelerate their Personalized Medicine Programs by solving two great challenges resulting from the increased use of Next Generation Sequence (NGS) testing – scalability and handling the complexity of larger gene sets. PierianDx addresses these challenges by enabling clinical labs to streamline workflow and access a single, integrated space that provides a curated knowledgebase, comprehensive analysis, insightful interpretation, and precise reporting. This “one-space” solution is PierianDx’s Clinical Genomicist Workspace (CGW) – a complete suite of solution modules accompanied by support services that provide a data-driven ecosystem for clinical labs to launch or expand their NGS testing programs.
Built and managed by a team of genomicists, pathologists, clinicians and software developers, PierianDx’s solution is now being used by leading academic medical centers, health systems, cancer centers, children’s hospitals and commercial labs worldwide.
PierianDx’s Cloud Story
PierianDx was looking to use cloud computing as a way to economically store large data sets resulting from their clients’ NGS testing and utilization of CGW. Each sequence of a human genome can be approximately 100 GB or more, so Pieri-anDx needed a scalable solution that would store terabytes of raw genomic data. Furthermore, processing genomic data in an expedient and economical fashion at scale is inherently a big data storage and analytics workload. PierianDx needed to scale compute resources in a massively parallel processing (MPP) architecture to increase the speed in which results were delivered, but only paying for resources they used when they used it. Additionally, the solution needed to be in an environment that meets Health Insurance Portability and Accountability Act (HIPAA) compliance requirements due to the sensitivity of human genome data. After conducting market research and due diligence, PierianDx chose Amazon Web Services as the cloud computing platform and REAN Cloud, an AWS Premier Consulting Partner, as a trusted partner to create the platform on AWS, manage the solution on a day-to-day basis, and continuously maintain HIPAA compliance.
Why PierianDx Chose REAN and AWS
PierianDx selected Amazon Web Services due to the complete platform of web services to provision IT infrastructure globally in a self-service model. AWS provided PierianDx a way to scale big data processing clusters on EC2 while automat-ing their genomics processing workflows. A trusted leader in the bioinformatics and genomics processing space, Globus Genomics, referred PierianDx to REAN Cloud. REAN Cloud and Globus Genomics had partnered previously on a HIPAA compliant pipeline on AWS Test Drive and co-developed a REAN Genomics processing solution. PierianDx chose REAN Cloud due to its deep expertise in security, compliance, and Amazon Web Services. REAN Cloud provided PierianDx a complete service offering that included: developing a hybrid architecture, migrating the solution into the AWS Cloud, and managing the entire environment on a daily basis while continuously meeting HIPAA compliance requirements with REAN Managed Services (MGS). By being able to provide end-to-end consulting and managed services, REAN Cloud was selected as a trusted consulting and operations partner.
PierianDx has been able to build an innovative genomics sequencing processing platform and solution that fully leverages the expertise of its clinical and biomedical research professionals without having to be burdened by undifferentiated heavy lifting of IT infrastructure and management. The powerful combination of using AWS and an AWS Consulting Partner, REAN Cloud, to provide infrastructure, security, and compliance, allows PierianDxto do what it does best – create better personalized medicine solutions to its customers.
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